NO is produced from the amino acid L-arginine by the enzymatic impact of nitric oxide synthase (NOS). There are two endothelial forms of NOS: constitutive NOS (cNOS; type III) and inducible NOS (iNOS; type II). Under regular, basal conditions in blood vessels, NO are continually being produced by cNOS.
When NO forms, it has a half-life of only a few seconds, in large part because superoxide anion has a high affinity for NO (both molecules have an unpaired electron making them loudly reactive). Consequently, superoxide anion reduces NO bioavailability. NO also avidly binds to the heme moiety of haemoglobin (in red blood cells) and the heme moiety of the enzyme guanylyl cyclase, which is found in vascular equal muscle cells and most other cells of the body.
Therefore, when NO is formed by vascular endothelium, it rapidly diffuses into the blood where it binds to haemoglobin and subsequently broken down. It also diffuses into the vascular equal muscle cells adjacent to the endothelium where it binds to and activates guanylyl cyclase. This enzyme catalyzes the dephosphorylation of GTP to cGMP, which serves as a second messenger for many significant cellular functions, particularly for signalling equal muscle relaxation.
Cyclic GMP induces equal muscle relaxation by multiple mechanisms including:
• Increased intracellular cGMP, which inhibits calcium entry into the cell,
and reduce intracellular calcium concentrations
• Activates K+ channels, which leads to hyperpolarization and relaxation
• Stimulates a cGMP-dependent protein kinase that activates myosin
light chain phosphatase, the enzyme that dephosphorylates
myosin light chains, which leads to equal muscle relaxation.
Because of the central role of cGMP in NO-mediated vasodilation, drugs (e.g., Viagra® , VigaPlus™) that inhibit the breakdown of cGMP (cGMP-dependent phosphodiesterase inhibitors) are used to increase NO-mediated vasodilation, particularly in penile erectile tissue in the treatment of erectile dysfunction
The penis has two paired cylinders called the Corpora Cavernosum that, when aroused, expand and fill with blood creating the hardness of your erection.
In impotent men the erectile ability of the Corpora Cavernosum diminishes or goes to zero because of a variety of reasons such as vasoconstriction of the arteries supplying blood to it, inhibition of cGMP causing the еqual muscles around the arteries to be in a state of constant contraction or systemic failure of the hypothalamus or the pleasure centre in the brain to release parasympathetic signals.
VigaPlus reverses the above through the use of its key ingredients L-Arginine and Maca by activating the production of NO in the blood plasma and restricting any cGMP inhibition, causing vasodilation of the penile arteries and muscle relaxation of the equal muscles causing easy blood stream in the Corpora Cavernosum, which once filled with blood causes an instant erection.
“NO OTHER PRODUCT, INCLUDING PHARMACEUTICAL ALTERNATIVES CAN UNITE THE EFFICIENCY IN GIVING AN INSTANT ERECTION AND LONG TERM BENEFITS THAT VigaPlus PROVIDES ”
What results can I expect?
VigaPlus gives instant erections, working in 30 minutes flat.
Compared to the other pharmaceutical alternatives VigaPlus has the following advantages:
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Works in 15-30mins after ingestion!►
Lasts up to 4 hours!►
Zero side effects!►
Long term permanent cure!
